The article presents a justification of the values for refined safety factors used in the design of buildings and structures made of large reinforced concrete modules. The relevance of the study is determined by the need to account for the specific features of industrial production of reinforced concrete structures, the high accuracy of factory manufacturing, the reduced variability of concrete strength characteristics, and the capabilities of modern numerical calculation methods. Numerical studies were carried out for individual large reinforced concrete modules, as well as for buildings with frame-wall and wall structural systems. The analyses were performed in linear, nonlinear dynamic, and probabilistic formulations using the LIRA-SAPR and ANSYS/LS-DYNA software packages, as well as the Python programming language. The strength of concrete and reinforcement, snow load, wind load, and uniformly distributed imposed load were considered as random variables. Based on the Monte Carlo simulation method, values of the probability of failure and the reliability index were obtained for buildings made of large reinforced concrete modules. It is shown that, for the structural systems under consideration, the calculated reliability indices exceed the target levels established in regulatory documents on the reliability of building structures. The obtained results make it possible to justify the refinement of individual partial safety factors while maintaining the required safety level of buildings made of large rein-forced.